The Thermo Scientific Dionex AutoTrace 280 PFAS performs automated solid phase extraction (SPE) for PFAS sample preparation, thereby reducing the risk of background contamination by using non-fluoropolymer-based tubing, valves, and filters. This instrument removes potential interferences from the analysis, while improving extraction recovery and reproducibility with precise flow-rate control. Throughput is increased by processing six samples at a time with minimal user engagement. AutoTrace 280 PFAS ensures compliance with regulated methods such as U.S. EPA 537, 537.1 and 533.